At this lunch & learn in Chicago, Cogstate Distinguished Medical Adviser, Dr. Eric Siemers, discussed combination therapies for Alzheimer's disease; addressing the questions “Which drugs?”, “Which patients?”, and “Which companies?”.
Dr. Siemers’ experience in clinical trials of neurodegenerative disease spans over 25 years, with a research focus on the use of biomarkers in investigational drug research, the development of trial designs that fully characterize the effects of investigational drugs on chronic diseases, and more specifically, the development of strategies for treating individuals before the onset of symptoms of neurodegenerative diseases.
Dr. Siemers most recently served as Distinguished Medical Fellow for Eli Lilly and Company’s Alzheimer’s Disease Global Development Team, where he was responsible for the design and implementation of 5 large phase III clinical studies of AD sponsored by Lilly, in addition to playing a major collaborative role in 2 public-private partnership studies. Prior to his appointments at Lilly, Dr. Siemers founded and headed the Indiana University Movement Disorder Clinic; his research there included investigations of Parkinson’s disease and Huntington’s disease, and he established one of the first centers for surgical PD treatments in the US.
Dr. Siemers is a member of the NIA/Alzheimer’s Association working group that will evaluate biomarkers and clinical symptoms in the nomenclature used for research of the entire Alzheimer’s disease continuum, and was previously a member of the working group that proposed criteria for preclinical Alzheimer’s disease in 2011. He also served on the Board of Directors of the American Society of Experimental Neurotherapeutics, as founding member and Chair of the Alzheimer’s Association Research Roundtable, and Steering Committee member for the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Dr. Siemers earned his MD with highest distinction from the Indiana University School of Medicine, where he completed an internship in the Department of Internal Medicine and residency in the Department of Neurology.